منابع مشابه
Esophageal Carcinogenesis
Esophageal cancer is the sixth leading cause of cancer death and remains one of the least survivable cancers. Esophageal cancers show wide variations in incidence in different population, suggesting that environmental or lifestyle risk factors could be controlled to reduce risk of these diseases. There are two major histopathologic types (squamous cell carcinoma and adenocarcinoma) of esophagea...
متن کاملDfmo Inhibits Nmba-induced Esophageal Carcinogenesis
that [miii an untreated, zinc-deficient (Zn—IDFMO—) animal (Fig. 1, B tersii.s†̃1 ).To a lesserdegree,theesophagusfroma DFMO-treated, iinc-sultlcieiit (Zn+IDFMO+) rat also demonstrated more apoptotic cells than that from an untreated, zinc-sufficient (Zn+IDFMO—) aiiinial ( Fig. 1, D versus C). Quantitatively, the frequency of apoptotic bodies ( Al. %; Table 2), calculated as the number o...
متن کاملOral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice.
PURPOSE Squamous cell carcinoma of the oral cavity is one of the most common human neoplasms, and prevention of these carcinomas requires a better understanding of the carcinogenesis process and a model system in which cancer chemoprevention agents can be tested. We have developed a mouse model using the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in the drinking water to induce tumorigenesis i...
متن کاملAlterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
TP53 genes is one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic stability. The development of esophageal and gastric cancers is a multistep process resulting in successive accumulation of genetic alterations that culminates in the malignant transformation. Thus, this study highlights the participation of ...
متن کاملp53 mutation and protein accumulation during multistage human esophageal carcinogenesis.
Preinvasive lesions of squamous cell carcinoma are well defined morphologically and provide a model for multistage carcinogenesis. Since alterations in the p53 tumor suppressor gene occur frequently in invasive esophageal squamous cell carcinoma, we examined a set of preinvasive lesions to investigate the timing of p53 mutation. Surgically resected tissues from nine patients with esophageal squ...
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ژورنال
عنوان ژورنال: Open Journal of Pathology
سال: 2014
ISSN: 2164-6775,2164-6783
DOI: 10.4236/ojpathology.2014.44021